Curriculum vitae and list of publications.

Name:                Daniel FAVRE   (JPG) (JPG)  (JPG)                                                                                                             

Date of birth:   31st of january, 1964

Citizenship:      Lausanne, Switzerland

Education:   1974-1980 Collège Secondaire, Echallens: Scientific Section

1980-1983 Gymnase de la Cité, Lausanne: Scientific Section

1983-1985 University of Lausanne: 1st and 2nd Propedeutics, Biology

1985-1986 Military Service

1986-1987 University of Lausanne: Certificate in Animal Biology

1987-1988 University of Lausanne: Half-certificate in Human Physiology

                                                            Half-certificate in Pharmacology

                                                            Licence in Biology   (JPG)

1988-1990 University of Lausanne: Diploma in Biology, Dpt. of Virology: c/o Prof. R. Wittek. ("Etude de la régulation de la traduction d' ARN codant pour l' enzyme thymidine kinase du virus de la vaccine dans des extraits de cellules infectées").   (JPG)

1991-1993 Institute of Medical Microbiology, University of Berne, Switzerland:

Phil. nat. (Ph.D.) under supervision of Dr. phil. nat. M. R. Michel ("The role of Semliki Forest virus capsid protein as a regulatory element in viral infection")

16th of decembrer, 1993 : Dr. phil. nat. Examination: notion suma cum laude.   (JPG)

Jan. 1994-May 1994 Institut of Medical Microbiology, University of Berne: submission of scientific articles; redaction of two post-doctoral research grants.

Sept. 1994-March 1995 Post-doctorate c/o Dr. Ch. Borner, Dpt of Biochemistry, University of Fribourg, Switzerland ("Ciba-Geigy Jubilaums Stiftung"): expression of Semliki forest virus capsid protein in bcl-2 expressing cells.

April 1995-November 1997 Post-doctorate c/o Prof. N. Sonenberg, Dpt. of Biochemistry, McGill University, Montreal, Canada. Under the financial support of the Swiss National Foundation for the Scientific Research (FNRS).

March 1998-May 2000 c/o PD Dr. Luc Perrin, Central Laboratory of Virology, Geneva Cantonal Hospital, Switzerland.

June 2000-July 2003 c/o Prof. Christian Trépo, Institut National de la Santé et de la Recherche Médicale, INSERM U271, Lyon, France. Obtention of a "Poste Vert for foreign researchers".

October 2003 - December 2005 c/o Prof. Michael Fried, Abt. Gastroenterology and Hepatology, Dpt. Internal Medicine, Universitary Hospital, Zürich, Switzerland.

March 2006 Scientific advisor for the Swiss League against Vivisection, Thônex, Switzerland.

April 2006 c/o Prof. Florian Wurm, Laboratory of Cellular Biotechnology (LBTC),
Swiss Federal Institute of Technolgy Lausanne (EPFL), Switzerland


Research grants already obtained in the past.

Swiss National Science Foundation (Ph. D. thesis in Bern, post-doctoral stay in Montreal).

Ciba-Geigy Jubiläums Stiftung (post-doctoral stay in Fribourg).

Swiss League against Vivisection (post-doctoral stay in Geneva).

INSERM "Poste Vert" for foreign researchers (post-doctoral stay in Lyon).



List of publications.

Diploma work.

"Etude de la régulation de la traduction d'ARN codant pour l'enzyme thymidine kinase du virus de la vaccine dans des extraits de cellules infectées".

May 1990. Institut de Biologie Animale, University of Lausanne, Switzerland

Thesis work (Ph.D.).

"The role of Semliki Forest virus core protein as a regulatory element in viral infection".

December 1993. Institut of Medical Microbiology, University of Berne, Switzerland.

Publications.

(i) published.

Semliki Forest virus capsid protein expressed by a baculovirus recombinant. Favre, D., Studer, E., Nishimura, T., Weitz, M., and Michel, M.R. Arch. Virol. 132: 307-319 (1993).

Two nucleolar targeting signals in the N-terminal part of Semliki Forest virus capsid protein. Favre, D., Studer, E., and Michel, M.R. Arch. Virol. 137: 149-155 (1994).

Nuclear export of baculovirus nucleocapsids via immature pores formed by fusion between the inner and outer nuclear membrane. Nishimura, T., Favre, D., Durrenberger, M., Michel, M.R., Ishihara, I., and Koblet, H. Okajimas Folia Anat. Jpn. 71: 83-98 (1994).

Modulation of translational thermotolerance and thermoprotection by Semliki Forest virus capsid protein. Michel, M.R., Favre, D., Studer, E., Arrigo, A.-P., and Kempf, C.

Eur. J. Biochem. 223: 791-797 (1994).

Semliki Forest virus capsid protein inhibits the initiation of translation by activating the double-stranded RNA-dependent eiF-2 kinase. Favre, D., Studer, E., and Michel, M.R. Bioscience Reports 16: 485-511 (1996).

Generation of a translational extract from eukaryotic cells that have grown as monolayers. Favre, D. ALTEX 14: 107-110 (1997)

Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. Rom, E., Kim H.C., Gingras A.-C., Marcotrigiano J., Favre D., Olsen H., Burley S.K., and Sonenberg N. J. Biol. Chem. 273: 13104-13109 (1998).

Translational extracts active biologically in vitro obtained from eukaryotic monolayer cells: a versatile method for viral RNA studies. Favre, D. and Trépo C. J. Virol. Methods 92:177-181 (2001) 

Removal of cell-bound lipoproteins: a crucial step for the efficient infection of liver cells with hepatitis C virus in vitro. Favre, D., Berthillon, P. and Trépo, C. C. R. Acad. Sci III 324 : 1141-1148 (2001) 

Hépatite C in vitro – Elimination des lipoprotéines associées aux cellules : une étape importante pour l’obtention d’une infection efficace des hépatocytes humains par le virus de l’hépatite C (VHC) in vitro. Favre, D., Berthillon, P., et Trépo, C. Rev Med Suisse Romande 122: 205 (JPG)

Latent hepatitis B virus (HBV) infection and HBV DNA integration is associated with further transformation of hepatoma cells in vitro.
Favre, D, Petit, M.-A.,. and Trépo, C.  ALTEX 20 (3):131-142 (2003)  

Potential cellular receptors involved in hepatitis C virus entry into cells.
Daniel Favre, Beat Muellhaupt
Lipids in Health and Disease 2005, 4:9 (2005)  

Reactivation of creatine kinase by dithiothreitol prior to use in an in vitro translation extract.
Daniel Favre, Beat Muellhaupt
ALTEX 22: 259-264 (2005)  

Efficiency of hepatitis C virus infection in vitro
Daniel Favre, Nelson Fausto
American Journal of Pathology 171(1):373 (2007).  

Reverse transcriptase activity of hepatitis B virus polymerase in eukaryotic cell extracts in vitro
Daniel Favre
ALTEX 25 (3): 197-211 (2008)  

Patent.

Infection of eukaryotic cells with viruses

Patent pending

Prices.

20th of April, 2002 – Hôtel Cornavin, Geneva, Switzerland.
1st Price of the " Fondation Naef pour la Recherche In Vitro" (Hepatitis C virus in vitro). (JPG)

20th of September, 2003. 11. Kongress über Alternativen zu Tierversuchen, MEGAT, Linz, Austria.
Poster Price Linz 2003 (Infection of human hepatocyte cell lines with Hepatitis B and C viruses in vitro) (JPG)  

8th of November, 2003, Luxembourg-Ville, Luxembourg 1st Price of the "Anny Eck-Hieff - FISEA Price 2003"
(Study of Hepatitis viruses in vitro). (JPG) (JPG) In the press: ( 1 ) ( 2 )






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